The Synergistic Effect of Conditional<i>Pten</i>Loss and Oncogenic<i>K-ras</i>Mutation on Endometrial Cancer Development Occurs via Decreased Progesterone Receptor Action

Abstract excerpt

Endometrial cancer is the most common gynecological cancer. Estrogen-dependent endometrioid carcinoma is the most common type of endometrial cancer, and alterations in the expression of PTEN and K-ras have been associated with this disease. To study the roles of Pten and K-ras in endometrial cancer, we generated Pten ablation and oncogenic K-ras mutation in progesterone receptor positive cells...

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