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<i>In vivo</i> intra-uterine delivery of TAT-fused Cre recombinase and CRISPR/Cas9 editing unveil histopathology of Pten/p53-deficient endometrial cancers

2023-06-08

Abstract excerpt

<h4>ABSTRACT</h4> Pten and p53 are two of the most frequently mutated tumor suppressor genes in endometrial cancer. However, the functional consequences and histopathological manifestation of concomitant p53 and Pten loss of function alterations in the development of endometrial cancer is still controversial. Here, we demonstrate that simultaneous Pten and p53 deletion is sufficient to cause epithelial to mesench...

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Literature Corpus work
6f9aa71b-f10d-5087-95b2-adc26e9f6cff
DOI
10.1101/2023.06.08.544224
Open publication

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<i>In vivo</i> intra-uterine delivery of TAT-fused Cre recombinase and CRISPR/Cas9 editing unveil histopathology of Pten/p53-deficient endometrial cancersDOI 10.1101/2023.06.08.544224
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