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Article

Modeling glands with PTEN deficient cells and microscopic methods for assessing PTEN loss: endometrial cancer as a model.

Methods (San Diego, Calif.) - 1 May 2015

Eritja Núria, Santacana Maria, Maiques Oscar, Gonzalez-Tallada Xavier, Dolcet Xavier, Matias-Guiu Xavier

Abstract excerpt

PTEN is an important tumor suppressor gene. Interpreting PTEN deficiency in the appropriate microscopic context of cancer may be important to understand its role in tumor development and progression. This may be particularly relevant in heterogeneous tumors. Here, we discuss the usefulness of 3D cultures in understanding the consequences of PTEN inactivation in tissue architecture. Afterwards, we discuss the role...

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Source

Identifiers

PMID: 25461816
DOI: 10.1016/j.ymeth.2014.11.001

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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