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Article

Activated mutant p110α causes endometrial carcinoma in the setting of biallelic Pten deletion.

The American journal of pathology - 1 Apr 2015

Joshi Ayesha, Miller Christopher, Baker Suzanne J, Ellenson Lora H

Abstract excerpt

PTEN and PIK3CA mutations occur with high frequency in uterine endometrioid carcinoma (UEC). Although PTEN mutations are present in complex atypical hyperplasia and carcinoma, PIK3CA mutations are restricted to carcinoma. We generated mouse models harboring Pten loss and/or activated Pik3ca in the endometrial epithelium to investigate their respective roles in the pathogenesis of UEC. Presence of an activated...

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Share to Class I Phosphatidylinositol 3-Kinases
Share to Endometrial Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-akt

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Source

Open in PubMed Open full text

Identifiers

PMID: 25698082
DOI: 10.1016/j.ajpath.2014.12.019
PMCID: PMC4380850

Genes

PTEN
FOXO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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