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Article

An inducible knockout mouse to model the cell-autonomous role of PTEN in initiating endometrial, prostate and thyroid neoplasias.

Disease models & mechanisms - 1 May 2013

Mirantes Cristina, Eritja Núria, Dosil Maria Alba, Santacana Maria, Pallares Judit, Gatius Sónia, Bergadà Laura, Maiques Oscar, Matias-Guiu Xavier, Dolcet Xavier

Abstract excerpt

PTEN is one of the most frequently mutated tumor suppressor genes in human cancers. The role of PTEN in carcinogenesis has been validated by knockout mouse models. PTEN heterozygous mice develop neoplasms in multiple organs. Unfortunately, the embryonic lethality of biallelic excision of PTEN has inhibited the study of complete PTEN deletion in the development and progression of cancer. By crossing PTEN...

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Source

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Identifiers

PMID: 23471917
DOI: 10.1242/dmm.011445
PMCID: PMC3634654

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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An inducible knockout mouse to model the cell-autonomous role of PTEN in initiating endometrial, prostate and thyroid neoplasias.PMID 23471917Read ↗

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