Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ovarian insufficiency and CTNNB1 mutations drive malignant transformation of endometrial hyperplasia with altered PTEN/PI3K activities

19 Feb 2019

Abstract excerpt

Significance Our mouse model of endometrial cancer (EC) reveals the mechanism underlying the presence of multiple driver mutations in early EC along with the menopause-associated risk in endometrial carcinogenesis. Human ECs carry multiple driver mutations even when they are low grade, whereas a single driver mutation caused EC in previous mouse studies. Our study established that multiple driver mutations are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endometrial and Cervical Cancer Treatments
Share to Estrogen and related hormone effects
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30782821
DOI: 10.1073/pnas.1814506116

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ovarian insufficiency and CTNNB1 mutations drive malignant transformation of endometrial hyperplasia with altered PTEN/PI3K activitiesPMID 30782821Read ↗

Co-mutations of CTNNB1 and PTEN drive aggressive tumor progression in endometrial cancer.Semantic proximity Read ↗

A New Type of Endometrial Cancer Models in Mice Revealing the Functional Roles of Genetic Drivers and Exploring their Susceptibilities.Semantic proximity Read ↗

PI3K/PTEN/AKT Genetic Mouse Models of Endometrial Carcinoma.Semantic proximity Read ↗

Molecular and pathologic aspects of endometrial carcinogenesis.Semantic proximity Read ↗

Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice.Semantic proximity Read ↗

Triple negative endometrial cancer.Semantic proximity Read ↗

Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/Pten signaling pathways.Semantic proximity Read ↗

Mechanisms of mutant β-catenin in endometrial cancer progressionSemantic proximity Read ↗

Prognostic Analysis of PTEN Mutation in Endometrial CarcinomaSemantic proximity Read ↗

Endometrial carcinoma: pathology and genetics.Semantic proximity Read ↗

The Synergistic Effect of Conditional<i>Pten</i>Loss and Oncogenic<i>K-ras</i>Mutation on Endometrial Cancer Development Occurs via Decreased Progesterone Receptor ActionSemantic proximity Read ↗

The uterine epithelial loss of Pten is inefficient to induce endometrial cancer with intact stromal Pten.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.