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Article

ERBB2 Targeting Reveals a Significant Suppression of Tumorigenesis in Murine Endometrial Cancer with Pten Mutation.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Aug 2024

Dunston Krystina, Hunter Mark I, Johannesen Eric, Jung Jin-Seok, Kim Tae Hoon, Yoo Jung-Yoon, Jeong Jae-Wook

Abstract excerpt

Endometrial cancer is the most common gynecologic malignancy. PTEN is a negative regulator of PI3K signaling and is deficient in > 50% of primary human endometrial cancer. Amplification of ERBB2 promotes tumorigenesis and pathogenesis of several human cancers. However, the effect of ERBB2 targeting has not been studied in endometrial cancer with PTEN mutations. The murine model Pgrcre/+Erbb2f/fPtenf/f (Erbb2d/d...

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PMID: 38637476
DOI: 10.1007/s43032-024-01546-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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