Article
Cell-specific conditional deletion of Pten in the uterus results in differential phenotypes.
Gynecologic oncology - 1 Aug 2011
Daikoku Takiko, Jackson Lindsey, Besnard Valérie, Whitsett Jeffrey, Ellenson Lora Hedrick, Dey Sudhansu K
Abstract excerpt
OBJECTIVE: Endometrial cancer (EMC) is the most common gynecological malignancy. The etiology and the cell types that are conducive to EMC are not completely understood, provoking further studies. Our objective was to determine whether deletion of Pten specifically in the uterine stroma and myometrium induces cancer or manifests different phenotypes. METHODS: Pten(Amhr2(d/d)) mice with conditional deletion of...
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