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Article

Conditional abrogation of transforming growth factor-β receptor 1 in PTEN-inactivated endometrium promotes endometrial cancer progression in mice.

The Journal of pathology - 1 Sept 2017

Gao Yang, Lin Pengfei, Lydon John P, Li Qinglei

Abstract excerpt

Although a putative role for transforming growth factor-β (TGFB) signalling in the pathogenesis of human endometrial cancer has long been proposed, the precise function of TGFB signalling in the development and progression of endometrial cancer remains elusive. Depletion of phosphatase and tensin homologue (PTEN) in the mouse uterus causes endometrial cancer. To identify the potential role of TGFB signalling in...

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Source

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Identifiers

PMID: 28657664
DOI: 10.1002/path.4930
PMCID: PMC5568928

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Research trail→

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Conditional abrogation of transforming growth factor-β receptor 1 in PTEN-inactivated endometrium promotes endometrial cancer progression in mice.PMID 28657664Read ↗

Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice.Semantic proximity Read ↗

The uterine epithelial loss of Pten is inefficient to induce endometrial cancer with intact stromal Pten.Semantic proximity Read ↗

An inducible knockout mouse to model the cell-autonomous role of PTEN in initiating endometrial, prostate and thyroid neoplasias.Semantic proximity Read ↗

ERBB2 Targeting Reveals a Significant Suppression of Tumorigenesis in Murine Endometrial Cancer with Pten Mutation.Semantic proximity Read ↗

Cell-specific conditional deletion of Pten in the uterus results in differential phenotypes.Semantic proximity Read ↗

Ovarian insufficiency and CTNNB1 mutations drive malignant transformation of endometrial hyperplasia with altered PTEN/PI3K activitiesSemantic proximity Read ↗

Co-mutations of CTNNB1 and PTEN drive aggressive tumor progression in endometrial cancer.Semantic proximity Read ↗

Inactivation of TGF-β signaling and loss of PTEN cooperate to induce colon cancer in vivo.Semantic proximity Read ↗

<i>In vivo</i> intra-uterine delivery of TAT-fused Cre recombinase and CRISPR/Cas9 editing unveil histopathology of Pten/p53-deficient endometrial cancersSemantic proximity Read ↗

The Synergistic Effect of Conditional<i>Pten</i>Loss and Oncogenic<i>K-ras</i>Mutation on Endometrial Cancer Development Occurs via Decreased Progesterone Receptor ActionSemantic proximity Read ↗

<i>Lkb1</i>inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapySemantic proximity Read ↗

Akt-Mediated Phosphorylation and Activation of Estrogen Receptor α Is Required for Endometrial Neoplastic Transformation in <i>Pten</i>+/− MiceSemantic proximity Read ↗

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