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Article

The protein tyrosine phosphatase PTPN22 negatively regulates presentation of immune complex derived antigens.

Scientific reports - 23 Aug 2018

Clarke Fiona, Purvis Harriet A, Sanchez-Blanco Cristina, Gutiérrez-Martinez Enrique, Cornish Georgina H, Zamoyska Rose, Guermonprez Pierre, Cope Andrew P

Abstract excerpt

A C1858T single nucleotide polymorphism within PTPN22 (which encodes PTPN22R620W) is associated with an enhanced susceptibility to multiple autoimmune diseases including type 1 diabetes and rheumatoid arthritis. Many of the associated autoimmune diseases have an autoantibody component to their pathology. Fc receptors (FcRs) recognise autoantibodies when they bind to autoantigens and form immune complexes. After...

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Source

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Identifiers

PMID: 30139951
DOI: 10.1038/s41598-018-31179-x
PMCID: PMC6107551

Genes

PTPN22

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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