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Article

Protein tyrosine phosphatase PTPN22 regulates LFA-1 dependent Th1 responses.

Journal of autoimmunity - 1 Nov 2018

Sanchez-Blanco Cristina, Clarke Fiona, Cornish Georgina H, Depoil David, Thompson Stephen J, Dai Xuezhi, Rawlings David J, Dustin Michael L, Zamoyska Rose, Cope Andrew P, Purvis Harriet A

Abstract excerpt

A missense C1858T single nucleotide polymorphism within PTPN22 is a strong genetic risk factor for the development of multiple autoimmune diseases. PTPN22 encodes a protein tyrosine phosphatase that negatively regulates immuno-receptor proximal Src and Syk family kinases. Notably, PTPN22 negatively regulates kinases downstream of T-cell receptor (TCR) and LFA-1, thereby setting thresholds for T-cell activation....

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Source

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Identifiers

PMID: 30054208
DOI: 10.1016/j.jaut.2018.07.008
PMCID: PMC6198113

Genes

PTPN22

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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