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Protein tyrosine phosphatase PTPN22 regulates IL-1β dependent Th17 responses by modulating dectin-1 signaling in mice.

European journal of immunology - 1 Feb 2018

Purvis Harriet A, Clarke Fiona, Jordan Christine K, Blanco Cristina Sanchez, Cornish Georgina H, Dai Xuezhi, Rawlings David J, Zamoyska Rose, Cope Andrew P

Abstract excerpt

A single nucleotide polymorphism within the PTPN22 gene is a strong genetic risk factor predisposing to the development of multiple autoimmune diseases. PTPN22 regulates Syk and Src family kinases downstream of immuno-receptors. Fungal β-glucan receptor dectin-1 signals via Syk, and dectin-1 stimulation induces arthritis in mouse models. We investigated whether PTPN22 regulates dectin-1 dependent immune...

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Autoimmune Diseases
Coculture Techniques
Dendritic Cells
Interleukin-1beta
Lectins, C-Type

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Tyrosine Phosphatase, Non-Receptor Type 22

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PMID: 28948613
DOI: 10.1002/eji.201747092
PMCID: PMC5859948

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PTPN22

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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