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Article

PTPN22: the archetypal non-HLA autoimmunity gene.

Nature reviews. Rheumatology - 1 Oct 2014

Stanford Stephanie M, Bottini Nunzio

Abstract excerpt

PTPN22 encodes a tyrosine phosphatase that is expressed by haematopoietic cells and functions as a key regulator of immune homeostasis by inhibiting T-cell receptor signalling and by selectively promoting type I interferon responses after activation of myeloid-cell pattern-recognition receptors. A single nucleotide polymorphism of PTPN22, 1858C>T (rs2476601), disrupts an interaction motif in the protein, and is...

Read the complete abstract on PubMed

Topics

Animals
Arthritis, Rheumatoid
Autoimmune Diseases
Autoimmunity
B-Lymphocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genome-Wide Association Study

Humans

Immune System Diseases

Mice

Models, Immunological

Polymorphism, Single Nucleotide

Protein Tyrosine Phosphatase, Non-Receptor Type 22

T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 25003765
DOI: 10.1038/nrrheum.2014.109
PMCID: PMC4375551

Genes

PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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