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Article

Influence of PTPN22 Allotypes on Innate and Adaptive Immune Function in Health and Disease.

Frontiers in immunology - 1 Jan 2021

Armitage Lucas H, Wallet Mark A, Mathews Clayton E

Abstract excerpt

Protein tyrosine phosphatase, non-receptor type 22 (PTPN22) regulates a panoply of leukocyte signaling pathways. A single nucleotide polymorphism (SNP) in PTPN22, rs2476601, is associated with increased risk of Type 1 Diabetes (T1D) and other autoimmune diseases. Over the past decade PTPN22 has been studied intensely in T cell receptor (TCR) and B cell receptor (BCR) signaling. However, the effect of the minor...

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Identifiers

PMID: 33717184
DOI: 10.3389/fimmu.2021.636618
PMCID: PMC7946861

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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