Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD22 and Autoimmune Disease

19 Oct 2012

Abstract excerpt

CD22 is a 140-kDa member of the Siglec family of cell surface proteins that is expressed by most mature B-cell lineages. As a co-receptor of the B-cell receptor (BCR), it is known to contribute to the sensitive control of the B-cell response to antigen. Cross-linking of CD22 and the BCR by antigen triggers the phosphorylation of CD22, which leads to activation of signaling molecules such as phosphatases. Signal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Lymphocytic Leukemia Research
Share to Lymphoma Diagnosis and Treatment
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23083346
DOI: 10.3109/08830185.2012.709890

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD22 and Autoimmune DiseasePMID 23083346Read ↗

Expression of aberrant forms of CD22 on B lymphocytes in Cd22a lupus-prone mice affects ligand binding.Semantic proximity Read ↗

B cell signaling and autoimmune diseases: CD19/CD22 loop as a B cell signaling device to regulate the balance of autoimmunitySemantic proximity Read ↗

B cell antigen receptor-evoked calcium influx is enhanced in CD22-deficient B cell lines.Semantic proximity Read ↗

Deficiency in CD22, a B cell-specific inhibitory receptor, is sufficient to predispose to development of high affinity autoantibodies.Semantic proximity Read ↗

Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease.Semantic proximity Read ↗

The role of PTPN22 in the pathogenesis of autoimmune diseases: A comprehensive review.Semantic proximity Read ↗

CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1.Semantic proximity Read ↗

CD22 ligand binding regulates normal and malignant B lymphocyte survival in vivo.Semantic proximity Read ↗

The protein tyrosine phosphatase PTPN22 negatively regulates presentation of immune complex derived antigens.Semantic proximity Read ↗

Lack of the phosphatase PTPN22 increases adhesion of murine regulatory T cells to improve their immunosuppressive function.Semantic proximity Read ↗

Regulation of autoimmune and anti-tumour T-cell responses by PTPN22.Semantic proximity Read ↗

The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.