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Article

Protein tyrosine phosphatase PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells.

PloS one - 1 Jan 2017

Clarke Fiona, Jordan Christine K, Gutiérrez-Martinez Enrique, Bibby Jack A, Sanchez-Blanco Cristina, Cornish Georgina H, Dai Xuezhi, Rawlings David J, Zamoyska Rose, Guermonprez Pierre, Cope Andrew P, Purvis Harriet A

Abstract excerpt

The PTPN22R620W single nucleotide polymorphism increases the risk of developing multiple autoimmune diseases including type 1 diabetes, rheumatoid arthritis and lupus. PTPN22 is highly expressed in antigen presenting cells (APCs) where the expression of the murine disease associated variant orthologue (Ptpn22R619W) is reported to dysregulate pattern recognition receptor signalling in dendritic cells (DCs) and...

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Identifiers

PMID: 29040339
DOI: 10.1371/journal.pone.0186625
PMCID: PMC5645108

Genes

PTPN22

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