Genetic fine mapping of systemic lupus erythematosus MHC associations in Europeans and African Americans.

doi:10.1093/hmg/ddy280

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Article

Genetic fine mapping of systemic lupus erythematosus MHC associations in Europeans and African Americans.

Human molecular genetics - 1 Nov 2018

Hanscombe Ken B, Morris David L, Noble Janelle A, Dilthey Alexander T, Tombleson Philip, Kaufman Kenneth M, Comeau Mary, Langefeld Carl D, Alarcon-Riquelme Marta E, Gaffney Patrick M, Jacob Chaim O, Sivils Kathy L, Tsao Betty P, Alarcon Graciela S, Brown Elizabeth E, Croker Jennifer, Edberg Jeff, Gilkeson Gary, James Judith A, Kamen Diane L, Kelly Jennifer A, McCune Joseph, Merrill Joan T, Petri Michelle, Ramsey-Goldman Rosalind, Reveille John D, Salmon Jane E, Scofield Hal, Utset Tammy, Wallace Daniel J, Weisman Michael H, Kimberly Robert P, Harley John B, Lewis Cathryn M, Criswell Lindsey A, Vyse Timothy J

Abstract excerpt

Genetic variation within the major histocompatibility complex (MHC) contributes substantial risk for systemic lupus erythematosus, but high gene density, extreme polymorphism and extensive linkage disequilibrium (LD) have made fine mapping challenging. To address the problem, we compared two association techniques in two ancestrally diverse populations, African Americans (AAs) and Europeans (EURs). We observed a...

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PMID: 30085094
DOI: 10.1093/hmg/ddy280
PMCID: PMC6196648

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