Article
Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups.
Annals of the rheumatic diseases - 1 Mar 2013
Kaufman Kenneth M, Zhao Jian, Kelly Jennifer A, Hughes Travis, Adler Adam, Sanchez Elena, Ojwang Joshua O, Langefeld Carl D, Ziegler Julie T, Williams Adrienne H, Comeau Mary E, Marion Miranda C, Glenn Stuart B, Cantor Rita M, Grossman Jennifer M, Hahn Bevra H, Song Yeong Wook, Yu Chack-Yung, James Judith A, Guthridge Joel M, Brown Elizabeth E, Alarcón Graciela S, Kimberly Robert P, Edberg Jeffrey C, Ramsey-Goldman Rosalind, Petri Michelle A, Reveille John D, Vilá Luis M, Anaya Juan-Manuel, Boackle Susan A, Stevens Anne M, Freedman Barry I, Criswell Lindsey A, Pons Estel Bernardo A, Lee Joo-Hyun, Lee Ji-Seon, Chang Deh-Ming, Scofield R Hal A, Gilkeson Gary S, Merrill Joan T, Niewold Timothy B, Vyse Timothy James, Bae Sang-Cheol, Alarcón-Riquelme Marta E, Jacob Chaim O, Moser Sivils Kathy, Gaffney Patrick M, Harley John B, Sawalha Amr H, Tsao Betty P
Abstract excerpt
OBJECTIVES: The Xq28 region containing IRAK1 and MECP2 has been identified as a risk locus for systemic lupus erythematosus (SLE) in previous genetic association studies. However, due to the strong linkage disequilibrium between IRAK1 and MECP2, it remains unclear which gene is affected by the underlying causal variant(s) conferring risk of SLE. METHODS: We fine-mapped ≥136 SNPs in a ∼227 kb region on Xq28,...
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