Article
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC.
Nature genetics - 1 Oct 2006
de Bakker Paul I W, McVean Gil, Sabeti Pardis C, Miretti Marcos M, Green Todd, Marchini Jonathan, Ke Xiayi, Monsuur Alienke J, Whittaker Pamela, Delgado Marcos, Morrison Jonathan, Richardson Angela, Walsh Emily C, Gao Xiaojiang, Galver Luana, Hart John, Hafler David A, Pericak-Vance Margaret, Todd John A, Daly Mark J, Trowsdale John, Wijmenga Cisca, Vyse Tim J, Beck Stephan, Murray Sarah Shaw, Carrington Mary, Gregory Simon, Deloukas Panos, Rioux John D
Abstract excerpt
The proteins encoded by the classical HLA class I and class II genes in the major histocompatibility complex (MHC) are highly polymorphic and are essential in self versus non-self immune recognition. HLA variation is a crucial determinant of transplant rejection and susceptibility to a large number of infectious and autoimmune diseases. Yet identification of causal variants is problematic owing to linkage...
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