Article
Genome-Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Apr 2016
Alarcón-Riquelme Marta E, Ziegler Julie T, Molineros Julio, Howard Timothy D, Moreno-Estrada Andrés, Sánchez-Rodríguez Elena, Ainsworth Hannah C, Ortiz-Tello Patricia, Comeau Mary E, Rasmussen Astrid, Kelly Jennifer A, Adler Adam, Acevedo-Vázquez Eduardo M, Cucho-Venegas Jorge Mariano, García-De la Torre Ignacio, Cardiel Mario H, Miranda Pedro, Catoggio Luis J, Maradiaga-Ceceña Marco, Gaffney Patrick M, Vyse Timothy J, Criswell Lindsey A, Tsao Betty P, Sivils Kathy L, Bae Sang-Cheol, James Judith A, Kimberly Robert P, Kaufman Kenneth M, Harley John B, Esquivel-Valerio Jorge A, Moctezuma José F, García Mercedes A, Berbotto Guillermo A, Babini Alejandra M, Scherbarth Hugo, Toloza Sergio, Baca Vicente, Nath Swapan K, Aguilar Salinas Carlos, Orozco Lorena, Tusié-Luna Teresa, Zidovetzki Raphael, Pons-Estel Bernardo A, Langefeld Carl D, Jacob Chaim O
Abstract excerpt
OBJECTIVE: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a strong genetic component. We undertook the present work to perform the first genome-wide association study on individuals from the Americas who are enriched for Native American heritage. METHODS: We analyzed 3,710 individuals from the US and 4 countries of Latin America who were diagnosed as having SLE, and healthy controls....
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