Article
HLA allele-calling using multi-ancestry whole-exome sequencing from the UK Biobank identifies 129 novel associations in 11 autoimmune diseases.
Communications biology - 3 Nov 2023
Butler-Laporte Guillaume, Farjoun Joseph, Nakanishi Tomoko, Lu Tianyuan, Abner Erik, Chen Yiheng, Hultström Michael, Metspalu Andres, Milani Lili, Mägi Reedik, Nelis Mari, Hudjashov Georgi, Yoshiji Satoshi, Ilboudo Yann, Liang Kevin Y H, Su Chen-Yang, Willett Julian D S, Esko Tõnu, Zhou Sirui, Forgetta Vincenzo, Taliun Daniel, Richards J Brent
Abstract excerpt
The human leukocyte antigen (HLA) region on chromosome 6 is strongly associated with many immune-mediated and infection-related diseases. Due to its highly polymorphic nature and complex linkage disequilibrium patterns, traditional genetic association studies of single nucleotide polymorphisms do not perform well in this region. Instead, the field has adopted the assessment of the association of HLA alleles...
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