Article
Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases.
Proceedings of the National Academy of Sciences of the United States of America - 3 Nov 2009
Rioux John D, Goyette Philippe, Vyse Timothy J, Hammarström Lennart, Fernando Michelle M A, Green Todd, De Jager Philip L, Foisy Sylvain, Wang Joanne, de Bakker Paul I W, Leslie Stephen, McVean Gilean, Padyukov Leonid, Alfredsson Lars, Annese Vito, Hafler David A, Pan-Hammarström Qiang, Matell Ritva, Sawcer Stephen J, Compston Alastair D, Cree Bruce A C, Mirel Daniel B, Daly Mark J, Behrens Tim W, Klareskog Lars, Gregersen Peter K, Oksenberg Jorge R, Hauser Stephen L
Abstract excerpt
The human MHC represents the strongest susceptibility locus for autoimmune diseases. However, the identification of the true predisposing gene(s) has been handicapped by the strong linkage disequilibrium across the region. Furthermore, most studies to date have been limited to the examination of a subset of the HLA and non-HLA genes with a marker density and sample size insufficient for mapping all independent...
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