Article
Inherited and Acquired Decrease in Complement Receptor 1 (CR1) Density on Red Blood Cells Associated with High Levels of Soluble CR1 in Alzheimer's Disease.
International journal of molecular sciences - 25 Jul 2018
Mahmoudi Rachid, Feldman Sarah, Kisserli Aymric, Duret Valérie, Tabary Thierry, Bertholon Laurie-Anne, Badr Sarah, Nonnonhou Vignon, Cesar Aude, Neuraz Antoine, Novella Jean Luc, Cohen Jacques Henri Max
Abstract excerpt
The complement receptor 1 (CR1) gene was shown to be involved in Alzheimer's disease (AD). We previously showed that AD is associated with low density of the long CR1 isoform, CR1*2 (S). Here, we correlated phenotype data (CR1 density per erythrocyte (CR1/E), blood soluble CR1 (sCR1)) with genetic data (density/length polymorphisms) in AD patients and healthy controls. CR1/E was enumerated using flow cytometry,...
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