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Alzheimer’s disease-associated complement gene variants influence plasma complement protein levels

21 Jul 2023

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) has been associated with immune dysregulation in biomarker and genome-wide association studies (GWAS). GWAS hits include the genes encoding complement regulators clusterin (CLU) and complement receptor 1 (CR1), recognised as key players in AD pathology, and complement proteins have been proposed as biomarkers. MAIN BODY: To address whether changes in plasma complement protein...

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PMID: 37480051
DOI: 10.1186/s12974-023-02850-6

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