Article
Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites.
Molecular psychiatry - 1 Feb 2012
Brouwers N, Van Cauwenberghe C, Engelborghs S, Lambert J-C, Bettens K, Le Bastard N, Pasquier F, Montoya A Gil, Peeters K, Mattheijssens M, Vandenberghe R, Deyn P P De, Cruts M, Amouyel P, Sleegers K, Van Broeckhoven C
Abstract excerpt
Two multicentre genome-wide association (GWA) studies provided substantial evidence, implicating the complement receptor 1 gene (CR1) in Alzheimer disease (AD) genetic etiology. CR1 encodes a large transmembrane receptor with a crucial role in the immune complement cascade. We performed a genetic follow-up of the GWA CR1 association in a Flanders-Belgian cohort (n=1883), and investigated the effect of...
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