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Article

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment.

Journal of visualized experiments : JoVE - 18 Jul 2017

Kisserli Aymric, Tabary Thierry, Cohen Jacques Henri Max, Duret Valérie, Mahmoudi Rachid

Abstract excerpt

Complement receptor 1 (CR1), a transmembrane glycoprotein that plays a key role in the innate immune system, is expressed on many cell types, but especially on red blood cells (RBCs). As a receptor for the complement components C3b and C4b, CR1 regulates the activation of the complement cascade and promotes the phagocytosis of immune complexes and cellular debris, as well as the amyloid-beta (Aβ) peptide in...

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Identifiers

PMID: 28745649
DOI: 10.3791/56012
PMCID: PMC5612547

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