Article
Complement receptor 1 gene ( <i>CR1</i> ) intragenic duplication and risk of Alzheimer’s disease
2018-03-19
Abstract excerpt
Single nucleotide variants (SNVs) within and surrounding the complement receptor 1 ( CR1 ) gene show some of the strongest genome-wide association signals with late-onset Alzheimer’s disease. Some studies have suggested that this association signal is due to a duplication allele ( CR1 -B) of a low copy repeat (LCR) within the CR1 gene, which increases the number of complement C3b/C4b-binding sites in the mature...
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Identifiers and source
- Literature Corpus work
- d0b8a5c3-7076-52b8-8d14-de12149ddf96
- DOI
- 10.1101/284711