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Article

A coding variant in CR1 interacts with APOE-ε4 to influence cognitive decline.

Human molecular genetics - 15 May 2012

Keenan Brendan T, Shulman Joshua M, Chibnik Lori B, Raj Towfique, Tran Dong, Sabuncu Mert R, Allen April N, Corneveaux Jason J, Hardy John A, Huentelman Matthew J, Lemere Cynthia A, Myers Amanda J, Nicholson-Weller Anne, Reiman Eric M, Evans Denis A, Bennett David A, De Jager Philip L

Abstract excerpt

Complement receptor 1 (CR1) is an Alzheimer's disease (AD) susceptibility locus that also influences AD-related traits such as episodic memory decline and neuritic amyloid plaque deposition. We implemented a functional fine-mapping approach, leveraging intermediate phenotypes to identify functional variant(s) within the CR1 locus. Using 1709 subjects (697 deceased) from the Religious Orders Study and the Rush...

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Topics

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Share to Alzheimer Disease
Share to Apolipoprotein E4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cognition Disorders

Share to Genome-Wide Association Study

Share to Memory, Episodic

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Share to Plaque, Amyloid

Share to Receptors, Complement

Source

Open in PubMed Open full text

Identifiers

PMID: 22343410
DOI: 10.1093/hmg/dds054
PMCID: PMC3335317

Genes

CR1
APOE

Variants

rs4844609

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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