Article

Dissecting DNA-mismatch-repair-driven mutational processes in human cells

2025-02-12

Abstract excerpt

Mismatch repair (MMR) is a crucial DNA repair pathway that maintains genomic integrity by correcting replication errors and various forms of DNA damage. MMR deficiency (MMRd) leads to increased mutation rates, microsatellite instability, and contributes to tumorigenesis in multiple cancer types. Using a CRISPR-Cas9-mediated knockout assay in human isogenic cell lines, we characterised mutational profiles in MMR-de...

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Literature Corpus work: a7c7bb77-1d05-5323-a059-e150a247930c
DOI: 10.1101/2025.02.10.637460

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