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Article

Ca2+-activated K+ channels modulate microglia affecting motor neuron survival in hSOD1G93A mice.

Brain, behavior, and immunity - 1 Oct 2018

Cocozza Germana, di Castro Maria Amalia, Carbonari Laura, Grimaldi Alfonso, Antonangeli Fabrizio, Garofalo Stefano, Porzia Alessandra, Madonna Michele, Mainiero Fabrizio, Santoni Angela, Grassi Francesca, Wulff Heike, D'Alessandro Giuseppina, Limatola Cristina

Abstract excerpt

Recent studies described a critical role for microglia in amyotrophic lateral sclerosis (ALS), where these CNS-resident immune cells participate in the establishment of an inflammatory microenvironment that contributes to motor neuron degeneration. Understanding the mechanisms leading to microglia activation in ALS could help to identify specific molecular pathways which could be targeted to reduce or delay motor...

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Identifiers

PMID: 29981425
DOI: 10.1016/j.bbi.2018.07.002
PMCID: PMC6129409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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