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Article

Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy.

Nature neuroscience - 1 Mar 2018

Spiller Krista J, Restrepo Clark R, Khan Tahiyana, Dominique Myrna A, Fang Terry C, Canter Rebecca G, Roberts Christopher J, Miller Kelly R, Ransohoff Richard M, Trojanowski John Q, Lee Virginia M-Y

Abstract excerpt

Though motor neurons selectively degenerate in amyotrophic lateral sclerosis, other cell types are likely involved in this disease. We recently generated rNLS8 mice in which human TDP-43 (hTDP-43) pathology could be reversibly induced in neurons and expected that microglia would contribute to neurodegeneration. However, only subtle microglial changes were detected during disease in the spinal cord, despite...

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Identifiers

PMID: 29463850
DOI: 10.1038/s41593-018-0083-7
PMCID: PMC5857237

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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