Article

KCa3.1 Contributes to Neuroinflammation and Nigral Dopaminergic Neurodegeneration in Experimental models of Parkinson’s Disease

2025-03-18

Abstract excerpt

Chronic neuroinflammation and misfolded α-synuclein (αSyn) have been identified as key pathological correlates driving Parkinson’s disease (PD) pathogenesis; however, the contribution of ion channels to microglia activation in the context of α-synucleinopathy remains elusive. Herein, we show that KCa3.1, a calcium-activated potassium channel, is robustly upregulated within microglia in multiple preclinical models...

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Literature Corpus work: 56641e86-e15e-5f83-95e7-463531e7eefb
DOI: 10.1101/2025.03.18.643982

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