Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Accelerated neurodegeneration and neuroinflammation in transgenic mice expressing P301L tau mutant and tau-tubulin kinase 1.

The American journal of pathology - 1 Mar 2014

Asai Hirohide, Ikezu Seiko, Woodbury Maya E, Yonemoto Grant M S, Cui Libin, Ikezu Tsuneya

Abstract excerpt

Tau-tubulin kinase-1 (TTBK1) is a central nervous system (CNS)-specific protein kinase implicated in the pathological phosphorylation of tau. TTBK1-transgenic mice show enhanced neuroinflammation in the CNS. Double-transgenic mice expressing TTBK1 and frontotemporal dementia with parkinsonism-17-linked P301L (JNPL3) tau mutant (TTBK1/JNPL3) show increased accumulation of oligomeric tau protein in the CNS and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Frontotemporal Dementia
Share to Nerve Degeneration

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neurons

Share to Phosphorylation

Share to Protein Serine-Threonine Kinases

Share to Spinal Cord

Share to tau Proteins

Share to Tauopathies

Source

Open in PubMed Open full text

Identifiers

PMID: 24418258
DOI: 10.1016/j.ajpath.2013.11.026
PMCID: PMC3936332

Genes

TTBK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Accelerated neurodegeneration and neuroinflammation in transgenic mice expressing P301L tau mutant and tau-tubulin kinase 1.PMID 24418258Read ↗

Induction of inflammatory mediators and microglial activation in mice transgenic for mutant human P301S tau protein.Semantic proximity Read ↗

Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model.Semantic proximity Read ↗

Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice.Semantic proximity Read ↗

Presence of reactive microglia and neuroinflammatory mediators in a case of frontotemporal dementia with P301S mutation.Semantic proximity Read ↗

CCL2 Overexpression in the Brain Promotes Glial Activation and Accelerates Tau Pathology in a Mouse Model of Tauopathy.Semantic proximity Read ↗

Tau Overexpression Impacts a Neuroinflammation Gene Expression Network Perturbed in Alzheimer’s DiseaseSemantic proximity Read ↗

Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice.Semantic proximity Read ↗

ALS/FTD-linked TBK1 deficiency in microglia induces an aged-like microglial signature and drives social recognition deficits in miceSemantic proximity Read ↗

Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy.Semantic proximity Read ↗

Sustained Interleukin-1β overexpression exacerbates Tau pathology in a murine tauopathy model via cyclooxygenase-1Semantic proximity Read ↗

The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer’s diseaseSemantic proximity Read ↗

TIA1 Mediates Divergent Inflammatory Responses to Tauopathy in Microglia and MacrophagesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.