Article
Clemastine Confers Neuroprotection and Induces an Anti-Inflammatory Phenotype in SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis.
Molecular neurobiology - 1 Jan 2016
Apolloni Savina, Fabbrizio Paola, Parisi Chiara, Amadio Susanna, Volonté Cinzia
Abstract excerpt
Mutations in the Cu(2+)/Zn(2+) superoxide dismutase 1 (SOD1) gene underlie 14-23 % of familial and 1-7 % of sporadic cases of amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease characterized by a specific loss of motor neurons in the brain and spinal cord. Neuroinflammation and oxidative stress are emerging as key players in the pathogenesis of ALS, thus justifying the interest in glial...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.