Article
Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis.
Proceedings of the National Academy of Sciences of the United States of America - 24 Oct 2006
Beers David R, Henkel Jenny S, Xiao Qin, Zhao Weihua, Wang Jinghong, Yen Albert A, Siklos Laszlo, McKercher Scott R, Appel Stanley H
Abstract excerpt
The most common inherited form of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease affecting adult motoneurons, is caused by dominant mutations in the ubiquitously expressed Cu(2+)/Zn(2+) superoxide dismutase (SOD1). Recent studies suggest that glia may contribute to motoneuron injury in animal models of familial ALS. To determine whether the expression of mutant SOD1 (mSOD1(G93A)) in CNS...
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