Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Early functional deficit and microglial disturbances in a mouse model of amyotrophic lateral sclerosis.

PloS one - 1 Jan 2012

Gerber Yannick Nicolas, Sabourin Jean-Charles, Rabano Miriam, Vivanco Maria d M, Perrin Florence Evelyne

Abstract excerpt

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by selective motoneurons degeneration. There is today no clear-cut pathogenesis sequence nor any treatment. However growing evidences are in favor of the involvement, besides neurons, of several partners such as glia and muscles. To better characterize the time course of pathological events in an animal model that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis
Share to Astrocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Flow Cytometry

Share to Microglia

Share to Motor Activity

Share to Neuromuscular Junction

Share to Spinal Cord

Share to Superoxide Dismutase

Source

Open in PubMed Open full text

Identifiers

PMID: 22558300
DOI: 10.1371/journal.pone.0036000
PMCID: PMC3338492

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Early functional deficit and microglial disturbances in a mouse model of amyotrophic lateral sclerosis.PMID 22558300Read ↗

The review of the methods to obtain non-neuronal cells to study glial influence on Amyotrophic Lateral Sclerosis pathophysiology at molecular level in vitroSemantic proximity Read ↗

Early gene expression changes in spinal cord from SOD1G93A Amyotrophic Lateral Sclerosis animal modelSemantic proximity Read ↗

Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage.Semantic proximity Read ↗

Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS.Semantic proximity Read ↗

Significance of aberrant glial cell phenotypes in pathophysiology of amyotrophic lateral sclerosis.Semantic proximity Read ↗

Early pathogenesis in the adult-onset neurodegenerative disease amyotrophic lateral sclerosis.Semantic proximity Read ↗

Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1.Semantic proximity Read ↗

Early Signs of Neuroinflammation in the Postnatal Wobbler Mice Model of Amyotrophic Lateral SclerosisSemantic proximity Read ↗

Properties of Glial Cell at the Neuromuscular Junction are Incompatible with synaptic repair in the SOD1 <sup>G37R</sup> ALS mouse modelSemantic proximity Read ↗

Optimised and Rapid Pre-clinical Screening in the SOD1G93A Transgenic Mouse Model of Amyotrophic Lateral Sclerosis (ALS)Semantic proximity Read ↗

Treatment with an antibody directed against Nogo-A delays disease progression in the SOD1G93A mouse model of Amyotrophic lateral sclerosisSemantic proximity Read ↗

Astrocytes show reduced support of motor neurons with aging that is accelerated in a rodent model of ALSSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.