Article

Loss of CREST leads to neuroinflammatory responses and ALS-like motor defects in mice

2018-03-27

Abstract excerpt

<h4>SUMMARY</h4> Amyotrophic lateral sclerosis (ALS) is a late onset neurodegenerative disease with fast progression. Mutations of the CREST gene (also known as SS18L1 ) are identified in sporadic ALS patients. Whether CREST mutations may lead to ALS remained largely unclear. In this study, we showed that the ALS-related CREST-Q388X mutation exhibited loss-of-function effects. Importantly, we found that micro...

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Literature Corpus work: 1f207469-bc22-587d-bd0a-8755b88449ef
DOI: 10.1101/260133

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