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Article

Post-paralysis tyrosine kinase inhibition with masitinib abrogates neuroinflammation and slows disease progression in inherited amyotrophic lateral sclerosis.

Journal of neuroinflammation - 11 Jul 2016

Trias Emiliano, Ibarburu Sofía, Barreto-Núñez Romina, Babdor Joël, Maciel Thiago T, Guillo Matthias, Gros Laurent, Dubreuil Patrice, Díaz-Amarilla Pablo, Cassina Patricia, Martínez-Palma Laura, Moura Ivan C, Beckman Joseph S, Hermine Olivier, Barbeito Luis

Abstract excerpt

BACKGROUND: In the SOD1(G93A) mutant rat model of amyotrophic lateral sclerosis (ALS), neuronal death and rapid paralysis progression are associated with the emergence of activated aberrant glial cells that proliferate in the degenerating spinal cord. Whether pharmacological downregulation of such aberrant glial cells will decrease motor neuron death and prolong survival is unknown. We hypothesized that...

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Identifiers

PMID: 27400786
DOI: 10.1186/s12974-016-0620-9
PMCID: PMC4940876

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SOD1

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Post-paralysis tyrosine kinase inhibition with masitinib abrogates neuroinflammation and slows disease progression in inherited amyotrophic lateral sclerosis.PMID 27400786Read ↗

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