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Article

Kir6.1/K-ATP channel modulates microglia phenotypes: implication in Parkinson's disease.

Cell death & disease - 14 Mar 2018

Du Ren-Hong, Sun Hong-Bin, Hu Zhao-Li, Lu Ming, Ding Jian-Hua, Hu Gang

Abstract excerpt

Classical activation (M1 phenotype) and alternative activation (M2 phenotype) are the two polars of microglial activation states that can produce either neurotoxic or neuroprotective effects in the immune pathogenesis of Parkinson's disease (PD). Exploiting the beneficial properties of microglia cells by modulating their polarization states provides great potential for the treatment of PD. However, the mechanism...

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Identifiers

PMID: 29540778
DOI: 10.1038/s41419-018-0437-9
PMCID: PMC5852118

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