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Article

Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS.

Experimental neurology - 1 Sept 2012

Liao Bing, Zhao Weihua, Beers David R, Henkel Jenny S, Appel Stanley H

Abstract excerpt

Neuroinflammation is a prominent pathological feature in the spinal cords of patients with amyotrophic lateral sclerosis (ALS), as well as in transgenic mouse models of inherited ALS, and is characterized by activated microglia. Earlier studies showed that activated microglia play important roles in both motoneuron protection and injury. More recent studies investigating the pathoprogression of disease in ALS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22735487
DOI: 10.1016/j.expneurol.2012.06.011
PMCID: PMC4126417

Genes

BDNF

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