Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spinal but not cortical microglia acquire an atypical phenotype with high VEGF, galectin-3 and osteopontin, and blunted inflammatory responses in ALS rats.

Neurobiology of disease - 1 Sept 2014

Nikodemova Maria, Small Alissa L, Smith Stephanie M C, Mitchell Gordon S, Watters Jyoti J

Abstract excerpt

Activation of microglia, CNS resident immune cells, is a pathological hallmark of amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder affecting motor neurons. Despite evidence that microglia contribute to disease progression, the exact role of these cells in ALS pathology remains unknown. We immunomagnetically isolated microglia from different CNS regions of SOD1(G93A) rats at three different points...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arginase
Share to Brain-Derived Neurotrophic Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Galectin 3

Share to Microglia

Share to Osteopontin

Share to Rats, Transgenic

Share to Spinal Cord

Share to Superoxide Dismutase-1

Source

Open in PubMed Open full text

Identifiers

PMID: 24269728
DOI: 10.1016/j.nbd.2013.11.009
PMCID: PMC4079765

Genes

SOD1
BDNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spinal but not cortical microglia acquire an atypical phenotype with high VEGF, galectin-3 and osteopontin, and blunted inflammatory responses in ALS rats.PMID 24269728Read ↗

A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse ModelSemantic proximity Read ↗

Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS.Semantic proximity Read ↗

Mutant SOD1 G93A microglia have an inflammatory phenotype and elevated production of MCP-1.Semantic proximity Read ↗

IL-10 Controls Early Microglial Phenotypes and Disease Onset in ALS Caused by Misfolded Superoxide Dismutase 1.Semantic proximity Read ↗

Human VCP mutant ALS/FTD microglia display immune and lysosomal phenotypes independently of GPNMB.Semantic proximity Read ↗

ALS monocyte-derived microglia reveal cytoplasmic TDP-43 accumulation, DNA damage, and cell-specific impairment of phagocytosis associated with disease progressionSemantic proximity Read ↗

Human amyotrophic lateral sclerosis/motor neuron disease: The disease‐associated microglial pathway is upregulated while APOE genotype governs risk and survivalSemantic proximity Read ↗

Interleukin 4 modulates microglia homeostasis and attenuates the early slowly progressive phase of amyotrophic lateral sclerosis.Semantic proximity Read ↗

Significance of aberrant glial cell phenotypes in pathophysiology of amyotrophic lateral sclerosis.Semantic proximity Read ↗

ALS iPSC-derived microglia and motor neurons respond to astrocyte-targeted IL-10 and CCL2 modulationSemantic proximity Read ↗

Human amyotrophic lateral sclerosis/motor neuron disease: The disease-associated microglial pathway is upregulated and APOE ε2 is protectiveSemantic proximity Read ↗

Defective phagocytic function of induced microglia-like cells is correlated with rapid progression of sporadic ALSSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.