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Article

Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis.

Nature communications - 3 Jul 2018

Byun Sangwon, Kim Dong-Hyun, Ryerson Daniel, Kim Young-Chae, Sun Hao, Kong Bo, Yau Peter, Guo Grace, Xu H Eric, Kemper Byron, Kemper Jongsook Kim

Abstract excerpt

Farnesoid-X-Receptor (FXR) plays a central role in maintaining bile acid (BA) homeostasis by transcriptional control of numerous enterohepatic genes, including intestinal FGF19, a hormone that strongly represses hepatic BA synthesis. How activation of the FGF19 receptor at the membrane is transmitted to the nucleus for transcriptional regulation of BA levels and whether FGF19 signaling posttranslationally...

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Identifiers

PMID: 29968724
DOI: 10.1038/s41467-018-04697-5
PMCID: PMC6030054

Genes

FGF19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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