Article
Mutation of PXR phosphorylation motif at Ser347 disrupts lipid and bile acid homeostasis in diet-induced metabolic dysfunction-associated steatohepatitis in mice.
Drug metabolism and disposition: the biological fate of chemicals - 1 Feb 2026
Basaly Veronia, Henry Zakiyah R, Taylor Rulaiha E, Kong Bo, Yang Ill, Brinker Anita, Yang Zhenning, Zhou Peihong, Joseph Laurie B, Aleksunes Lauren, Buckley Brian, Negishi Masahiko, Guo Grace L
Abstract excerpt
The pregnane X receptor (PXR), a ligand-activated transcription factor, regulates the expression of genes involved in endobiotic and xenobiotic metabolism, inflammation, and fibrosis. Disruption of PXR functions can affect processes critical to metabolic dysfunction-associated steatohepatitis (MASH) progression. Although ligand-dependent PXR functions are well studied, its regulation by post-translational...
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