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Article

A CK2-RNF4 interplay coordinates non-canonical SUMOylation and degradation of nuclear receptor FXR.

Journal of molecular cell biology - 1 Jun 2017

Bilodeau Stéphanie, Caron Véronique, Gagnon Jonathan, Kuftedjian Alexandre, Tremblay André

Abstract excerpt

Farnesoid X receptor (FXR) is a ligand-activated nuclear receptor that plays a central role in regulating genes involved in bile acid homeostasis, and fat and glucose metabolism. Here, we demonstrate a post-translational interplay between FXR phosphorylation, SUMOylation, and ubiquitination that directs the receptor into an activation-degradation pathway in hepatocytes. We identify a non-canonical SUMOylation...

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Share to Casein Kinase II
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28201649
DOI: 10.1093/jmcb/mjx009
PMCID: PMC5907841

Genes

RNF4
SUMO2
PIAS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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A CK2-RNF4 interplay coordinates non-canonical SUMOylation and degradation of nuclear receptor FXR.PMID 28201649Read ↗

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Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.Semantic proximity Read ↗

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