Article

Hepatic stellate cell FXR signaling regulates context-dependent functions in liver homeostasis and fibrosis.

2026-08-31

Abstract excerpt

Nuclear bile acid (BA) signaling plays a central role in liver homeostasis and represents a major therapeutic axis in fibrotic liver diseases. The farnesoid X receptor (FXR), a master nuclear effector of BA signaling, is expressed in several liver-resident cell types, suggesting that it may regulate distinct biological programs beyond the hepatocyte (HC) compartment. Using complementary pharmacological, genetic, a...

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Literature Corpus work: 783ca908-fae8-5071-941f-f8f8a576b5c4
DOI: 10.64898/2026.08.29.747537

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