Nuclear receptor FXR, bile acids and liver damage: Introducing the progressive familial intrahepatic cholestasis with FXR mutations.

doi:10.1016/j.bbadis.2017.09.019

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Back to search

Article

Nuclear receptor FXR, bile acids and liver damage: Introducing the progressive familial intrahepatic cholestasis with FXR mutations.

Biochimica et biophysica acta. Molecular basis of disease - 1 Apr 2018

Cariello Marica, Piccinin Elena, Garcia-Irigoyen Oihane, Sabbà Carlo, Moschetta Antonio

Abstract excerpt

The nuclear receptor farnesoid X receptor (FXR) is the master regulator of bile acids (BAs) homeostasis since it transcriptionally drives modulation of BA synthesis, influx, efflux, and detoxification along the enterohepatic axis. Due to its crucial role, FXR alterations are involved in the progression of a plethora of BAs associated inflammatory disorders in the liver and in the gut. The involvement of the FXR...

Topics

Animals
Bile Acids and Salts
Cholagogues and Choleretics
Cholestasis, Intrahepatic
Clinical Trials as Topic
Disease Models, Animal
Epithelial Cells
Fibroblast Growth Factors
Humans
Intestinal Mucosa

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Liver

Mice

Mice, Transgenic

Mutation

Receptors, Cytoplasmic and Nuclear

Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 28965883
DOI: 10.1016/j.bbadis.2017.09.019

Genes

FGF19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nuclear receptor FXR, bile acids and liver damage: Introducing the progressive familial intrahepatic cholestasis with FXR mutations.PMID 28965883Read ↗

Farnesoid x receptor in human metabolism and disease: the interplay between gene polymorphisms, clinical phenotypes and disease susceptibility.Semantic proximity Read ↗

Cholestasis and cholestatic syndromes.Semantic proximity Read ↗

Genetics in Familial Intrahepatic Cholestasis: Clinical Patterns and Development of Liver and Biliary Cancers: A Review of the LiteratureSemantic proximity Read ↗

Bile acid receptors in the biliary tree: TGR5 in physiology and disease.Semantic proximity Read ↗

Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis.Semantic proximity Read ↗

Genetics of familial intrahepatic cholestasis syndromes.Semantic proximity Read ↗

Cross-talk between bile acids and intestinal microbiota in host metabolism and healthSemantic proximity Read ↗

Progressive familial intrahepatic cholestasis (PFIC) type 1, 2, and 3: a review of the liver pathology findings.Semantic proximity Read ↗

Transcriptional regulation of hepatobiliary transport systems in health and disease: Implications for a rationale approach to the treatment of intrahepatic cholestasisSemantic proximity Read ↗

Role of pregnane X-receptor in regulating bacterial translocation in chronic liver diseasesSemantic proximity Read ↗

Current and future therapies for inherited cholestatic liver diseases.Semantic proximity Read ↗

Bile acid metabolism in health and ageing-related diseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.