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Article

Hepatocyte FRS2α is essential for the endocrine fibroblast growth factor to limit the amplitude of bile acid production induced by prandial activity.

Current molecular medicine - 1 Jan 2014

Wang Cong, Yang Chaofeng, Chang Julia Yf, You Pan, Li Yue, Jin Chengliu, Luo Yongde, Li Xiaokun, McKeehan Wallace L, Wang Fen

Abstract excerpt

In addition to being positively regulated by prandial activity, bile acid production is also negatively controlled by the endocrine fibroblast growth factor 19 (FGF19) or the mouse ortholog FGF15 from the ileum that represses hepatic cholesterol 7 α-hydroxylase (Cyp7a1) expression through activating FGF receptor four (FGFR4). However, how these two regulatory mechanisms interplay to control bile acid homeostasis...

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Source

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Identifiers

PMID: 25056539
DOI: 10.2174/1566524014666140724095112
PMCID: PMC4768716

Genes

FGFR4
FGF19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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