Article
Bile acid signal-induced phosphorylation of small heterodimer partner by protein kinase Cζ is critical for epigenomic regulation of liver metabolic genes.
The Journal of biological chemistry - 9 Aug 2013
Seok Sunmi, Kanamaluru Deepthi, Xiao Zhen, Ryerson Daniel, Choi Sung-E, Suino-Powell Kelly, Xu H Eric, Veenstra Timothy D, Kemper Jongsook Kim
Abstract excerpt
Bile acids (BAs) are recently recognized key signaling molecules that control integrative metabolism and energy expenditure. BAs activate multiple signaling pathways, including those of nuclear receptors, primarily farnesoid X receptor (FXR), membrane BA receptors, and FXR-induced FGF19 to regulate the fed-state metabolism. Small heterodimer partner (SHP) has been implicated as a key mediator of these BA...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.