Article

Sex differences in bile acid homeostasis and excretion underlie the disparity in liver cancer incidence between males and females

2020-06-27

Abstract excerpt

Hepatocellular carcinoma (HCC), the most common liver cancer, exhibits a higher incidence in males. Here, we report that mice lacking the bile acid regulators, Farnesoid X Receptor (FXR) and Small Heterodimer Partner (SHP), recapitulate the sex difference in liver cancer risk. Since few therapeutic options are available, we focused on understanding the intrinsic protection afforded to female livers. Transcriptomic...

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Literature Corpus work: c6bc4d30-eae0-540f-87a6-636f7b0b85ea
DOI: 10.1101/2020.06.25.172635

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