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Article

ATPase Class I Type 8B Member 1 and protein kinase C zeta induce the expression of the canalicular bile salt export pump in human hepatocytes.

Pediatric research - 1 Feb 2010

Chen Frank, Ellis Ewa, Strom Stephen C, Shneider Benjamin L

Abstract excerpt

The exact molecular mechanism(s) of the disease that results from defects in the ATPase Class I Type 8B Member 1 gene remains controversial. Prior investigations of human ileum and in intestinal and ovarian cell lines have suggested that familial intrahepatic cholestasis 1 (FIC1) activates the farnesoid X-receptor (FXR) via a pathway involving protein kinase C zeta (PKCzeta). Translational investigations of human...

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Share to ATP Binding Cassette Transporter, Subfamily B, Member 11

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Source

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Identifiers

PMID: 19809379
DOI: 10.1203/PDR.0b013e3181c2df16
PMCID: PMC2819672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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